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Innovations in Oral Solid Drug Delivery: Advances in nanotechnology, controlled formulations & peptide delivery

 
Table of Contents : 

Innovations in oral solid drug delivery
Executive summary 18
Market overview, dynamics and outlook 18
Advances in nanotechnology 19
Innovations in transitioning injectables to oral delivery 20
Advances in delayed & controlled release delivery 21
Advances in oral prodrug delivery 22
Advances in taste masking technologies 23
Innovative companies 24
Chapter 1 Market overview, dynamics and outlook 28
Summary 28
Market overview 29
Market dynamics 31
Key indications 33
Key trends 38
Nanomedicine 38
Transitioning from injectables 39
Prodrugs 40
Chrono release 41
ODT 41
OSF 42
Funding issues 42
Poor patient compliance 42
Injections 42
Poor absorbption 42
Pediatric 43
Geriatric 43
Solubility and variable absorption 43
Reduction of side effect profiles 44
Non-invasive protein delivery 45
Transition from injectables to preferred route of oral drug delivery 45
Directed delivery and delayed delivery to reduce side effect potential 46
Formulation technologies for poorly soluble compounds 46
Taste masking for pediatric and geriatric formulations 47
Competitive landscape 48
Conclusions and key findings 50
Chapter 2 Advances in nanotechnology 56
Summary 56
Introduction 57
Nanotechnology platforms with application for oral drug delivery 59
Self-Emulsifying Controlled Release Tablet system (SECRET) 59
Technology 59
Application 59
Biotransport nanomedicine technology 60
Technology 60
Application 60
Nanobodies 61
Technology 61
Application 61
NanoDel nanoparticles 62
Technology 62
Application 62
P-gpMask 63
Technology 63
Application 64
NanoDRY and NanoCOAT 64
Technology 64
Application 64
Solumer 67
Technology 67
Application 67
Nanocells 69
Technology 69
Application 70
Polymeric Nano-Delivery System (PNDS) 70
Technology 70
Application 71
FluidCrystal NP Oral nanoparticles 71
Technology 71
Application 72
CaP Technology and BioOral 72
Technology 72
Application 73
Nab Technology and Protospheres 73
Technology 73
Application 73
NanoCrystal Technology 74
Technology 74
Application 74
Bioral 75
Technology 75
Application 75
Squalenoyl nanoparticles 76
NanoMega 76
NOD Pharmaceutical 76
Chapter 3 Innovations in transitioning injectables to oral delivery 80
Summary 80
Introduction 81
Drivers 81
Patient acceptability & compliance 81
Cost savings 81
Restraints 82
Advances in injectable delivery 82
Challenges of oral drug delivery 83

Want to Live Extra Years?

Medicines do not simply enter the body and wander around until they finds something to cure, and getting compounds to their intended target is one of the biggest challenges for drug manufacturers. The virtual lab in NanoMission V2 allows you to go from the organ view down to individual cells, analyzing the cells compositions, traveling down the blood stream and seeing the medicine you’ve created in action.

Want to Live Extra Years?

Approximately 99 per cent of medicinal molecules don’t reach their targets and subsequently, stay in the body of the patient. As these molecules can sometimes be very toxic – particularly in the case of those designed to target cancers – research is being undertaken into more effective ways of safely transporting and delivering drugs. A challenge for nanotechnology in this research is to create a device which can carry a drug payload to it’s target, be monitored throughout it’s journey and deliver, without being attacked and destroyed by the body’s natural defences. This calls for something which possesses stealth design characteristics and a plausible device is described here in this movie. This is one of a selection of intriguing movies which are available for free download from the EPSRC Nanotechnology Image Library at : www.nanoscience.dept.shef.ac.uk You may also be interested in navigating to the “Soft Machines” site belonging to Professor Richard Jones – who features in this movie – for up-to-date discourse on all things nano. Here’s the link : www.softmachines.org

Want to Live Extra Years?